Cancer risk in mutation carriers of DNA‐mismatch‐repair genes
نویسندگان
چکیده
منابع مشابه
Prospective risk of cancer in CDKN2A germline mutation carriers.
BACKGROUND The CDKN2A gene is the major known high-risk melanoma susceptibility gene. Susceptibility to other cancers has also been suggested. However, most studies examining the risks of other cancers classified individuals according to the family's CDKN2A mutation rather than determining individual mutation status. For non-population-based studies, risks could also be biased because of cancer...
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چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولSelenium and cancer risk in CHEK2 mutation carriers
Checkpoint kinase 2 (CHEK2) is as an important signal transducer of cellular responses to DNA damage and acts as a tumour suppressor gene. Mutations in the CHEK2 gene have been shown to be associated with increased risks to several cancers. In Poland four mutations in CHEK2 gene (1100delC, IVS2+1G>A, I157T, del5395) have been identified. Studies on our population provided evidence that CHEK2 tr...
متن کاملStudy clarifies risk of breast, ovarian cancer among mutation carriers.
Women who inherit mutations in the BRCA1 and BRCA2 genes may have high lifetime risks for breast and ovarian cancer regardless of whether they have a family history of the cancers. That finding comes from the New York Breast Cancer Study (NYBCS), the most thorough analysis to date of cancer risks among women who carry the mutations. Risk levels found in the NYBCS are similar to those reported i...
متن کاملBreast cancer risk among male BRCA1 and BRCA2 mutation carriers.
Men who carry germline mutations in the BRCA2 gene have a higher risk of developing breast carcinoma than men in the general population. Men who carry germline mutations in the BRCA1 gene may also be at a higher risk for breast carcinoma, but this association is not as well established. We evaluated the risks of developing breast carcinoma for male BRCA1 and BRCA2 mutation carriers in the US po...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 1999
ISSN: 0020-7136,1097-0215
DOI: 10.1002/(sici)1097-0215(19990412)81:2<214::aid-ijc8>3.3.co;2-c